Description
Aries
Food supplement based on Rhodiola rosea L extract, Malpighia glabra L extract, vitamin B2, vitamin B6, vitamin B12, niacin, folate, pantothenic acid and vitamin E. Rhodiola rosea extract has a tonic-adaptogenic effect, a tonic effect for physical and mental fatigue and helps maintain normal mood. Malpighia glabra (acerola) extract supports the body's natural defenses and has a supporting, restorative and antioxidant effect. Vitamin B2, vitamin B6, vitamin B12, niacin, folate and pantothenic acid contribute to the reduction of tiredness and fatigue. Vitamin E contributes to the protection of cells from oxidative stress.Rhodiola rosea extract
Tonic-adaptogenic effect, tonic effect for physical and mental fatigue and promotes the maintenance of normal mood [1]. Rhodiola rosea extract is able to promote the normal functions of the nervous system and to support the body in adapting to stressful conditions. Rhodiola rosea has an adaptogenic effect, as it is able to influence various physiological parameters including neurotransmitters, the activity of the central nervous system and cardiovascular function [2]. Studies conducted on animal models have demonstrated the ability of the extract to increase physical performance under stress [3] by preventing the disturbance of the stress axis [4]. Studies conducted on humans have demonstrated its usefulness in asthenic conditions that develop following intense physical or intellectual activity, infections or other diseases [5]. They also highlighted that Rhodiola rosea can be a useful adjuvant in mood problems and in promoting attention, resistance to fatigue and performance in work, study, sports and usual daily activities [6,7,8,9]. The adaptogenic properties of Rhodiola rosea have been attributed mainly to its ability to influence the levels and activity of biogenic monoamines (serotonin, dopamine and noradrenaline), to facilitate the transport of neurotransmitters [10,11] and to activate the receptors of the nervous system [12].
Malpighia glabra extract
It promotes the body's natural defenses and has a supporting, restorative and antioxidant effect [1,13]. This extract is particularly rich in vitamin C and is also a source of beta-carotene [14].
Vitamin C (L-ascorbic acid)
They are due to its ability to oxidize and reduce reversibly. Ascorbic acid is the cofactor of enzymes that catalyze hydroxylation reactions, including the hydroxylation of DOPA for the formation of adrenaline and the hydroxylation of aromatic compounds in the liver. It also intervenes in cellular defense processes, promoting the elimination of free radicals by donating an electron to the tocopheryl radical and thus regenerating the antiradical activity of vitamin E. Vitamin C promotes the reduction of folic acid in its coenzyme forms and the intestinal absorption of iron. It is also involved in the synthesis of carnitine, useful for the synthesis of ATP, and in the metabolism of various hormones.
B-complex vitamins contribute to the reduction of tiredness and fatigue [15] as they are involved in the functions.
Vitamin B2
In the form of two flavin coenzymes (flavin mononucleotide or FMN and flavin dinucleotide or FAD), it constitutes the prosthetic group of enzymes involved in oxidation-reduction reactions, in particular in the oxidative decarboxylation of pyruvic acid, in the oxidation of fatty acids and amino acids and in the transport of electrons in the respiratory chain [16].
Vitamin B6
It is found bound to numerous enzymes that are mostly involved in the reactions of the metabolism of amino acids and other nitrogenous substances (transamination, decarboxylation and racemization). The good use of dietary proteins depends on the supply of this vitamin. Vitamin B6 is also involved in some reactions of carbohydrate metabolism (glycogenolysis) and lipid metabolism (synthesis of unsaturated fatty acids).
Vitamin B12
It participates in reactions such as the conversion of methylmalonyl-CoA to succinyl-CoA in the metabolism of propionic acid resulting from the catabolism of fatty acids or some amino acids. It is also involved in methyl metabolism, and therefore in the synthesis of methionine from homocysteine and other methylated compounds [17].
Niacin
In the form of coenzymes (nicotine adenine dinucleotide or NAD and nicotine adenine dinucleotide phosphate or NADP) it participates in numerous oxidation-reduction reactions, both in catabolic and anabolic processes, such as the synthesis of fatty acids and amino acids.
Folate
It has the function of transferring single-carbon units from one compound to another in the metabolism of amino acids and in the synthesis of nucleic acids and plays an essential role in many metabolic reactions in which vitamin B12 is also involved. In fact, it participates in the biosynthesis of DNA and RNA, in the methylation of homocysteine to methionine and in the metabolism of some amino acids (interconversion between glycine and serine and catabolism of histidine).
Pantothenic acid
It is the precursor of coenzyme A, a fundamental molecule in the metabolism of carbohydrates, amino acids, fatty acids and steroid compounds. Pantothenic acid is also part of the prosthetic group of Acyl-Carrier-Protein (ACP), a transport protein involved in the synthesis of fatty acids.
Vitamin E
It contributes to the protection of cells from oxidative stress[15]: it is the main fat-soluble antioxidant of the cellular antioxidant defense system. Inside the phospholipid bilayer of cell membranes it protects the polyunsaturated fatty acids of the membranes themselves from oxidation [18].
Ingredients
Rhodiola rosea L extract; Malpighia glabra L extract; vitamin B2; vitamin B6; vitamin B12; niacin; folate; pantothenic acid and vitamin E.
How to use
It is recommended to take one capsule once or twice a day with a glass of water.
Warnings
Do not exceed the maximum recommended daily dose. Keep out of the reach and sight of children under three years of age. Do not take during pregnancy. Supplements are not intended as a substitute for a varied diet and a healthy lifestyle.
Conservation
Store in a cool, dry place away from light, localized heat sources, sunlight and avoid contact with water. The expiry date refers to the product correctly stored, in an intact package.
Format
Box of 20 gastro-resistant capsules of 550 mg.
Bibliography
- 1. Ministerial Reference Guidelines for the physiological effects of herbal substances and preparations permitted in food supplements (http://www.salute.gov.it/imgs/C_17_pagineAree_3665_listaFile_itemName_1_file.pdf).
- 2.Kelly GS. Rhodiola rosea: a possible plant adaptogen. Altern Med Rev. 2001 Jun;6(3):293-302. Review.
- 3.Azizov AP, Seifulla RD. The effect of elton, leveton, phytoton and adaptation on the work capacity of experimental animals. Eksp Klin Farmakol. 1998;61:61-63.
- 4.Lishmanov IB, Trifonova ZV, Tsibin AN, et al. Plasma beta-endorphin and stress hormones in stress and adaptation. Biull Eksp Biol Med. 1987;103:422-424.
- 5.Germano C, Ramazanov Z, Bernal Suarez M. Arctic Root (Rhodiola rosea): The Powerful New Ginseng Alternative. New York, NY: Kensington Publishing Corp; 1999.
- 6.Darbinyan V, Kteyan A, Panossian A, et al. Rhodiola rosea in stress induced fatigue - a double blind cross-over study of a standardized extract SHR-5 with a repeated low-dose regimen on the mental performance of healthy physicians during night duty. Phytomedicine. 2000;7:365-371.
- 7. Spasov AA, Wikman GK, Mandrikov VB et al. A double-blind, placebo-controlled pilot study of the stimulating and adaptogenic effect of Rhodiola rosea SHR-5 extract on the fatigue of students caused by stress during an examination period with a repeated low-dose regimen. Phytomedicine. 2000;7:85-89.
- 8.De Bock K, Eijnde BO et al. Acute Rhodiola rosea intake can improve endrance exercise performance. Int J Sport Nutr Exerc Metab. 2004 Jun;14(3):298-307.
- 9.Shevtsov VA, Zholus BI et al. A randomized trial of two different doses of a SHR-5 Rhodiola rosea extract versus placebo and control of capacity for mental work. Phytomedicine. 2003 Mar;10(2-3):95-105.
- 10.Stancheva SL, Mosharrof A. Effect of the extract of Rhodiola rosea L. on the content of the brain biogenic monamines. Med Physiol. 1987;40:85-87.
- 11.Maslova LV, Kondrat'ev BI, Maslov LN, Lishmanov IB. The cardioprotective and antiadrenergic activity of an extract of Rhodiola rosea in stress. Eksp Klin Farmakol. 1994;57:61-63.
- 12.Lishmanov IB, Trifonova ZV, Tsibin AN, et al. Plasma beta-endorphin and stress hormones in stress and adaptation. Biull Eksp Biol Med. 1987;103:422-424.
- 13.Motohashi N, Wakabayashi H, Kurihara T et al. Biological activity of barbados cherry (acerola fruits, fruit of Malpighia emarginata DC) extracts and fractions. Phytother Res. 2004 Mar; 18(3):212-23.
- 14.Johnson PD. Acerola (Malpighia glabra L, M. Punicifolia L, M. emarginata DC): agriculture, production and nutrition. Simopoulos AP, Gopalan C (eds): Plants in Human Health and Nutrition Policy. Eorld Rev Nutr Diet. Basel, Karger, 2003, vol 91, 67-75.
- 15.EU Regulation No. 432/2012 of the Commission of 16 May 2012. List of permitted health claims.
- 16. Bates C. Riboflavin. Nutr. Research Review. 1994;7: 106-07.
- 17. Chanarin I. The Megaloblastic anemias. 2nd ed. Blackwell Scientific Publications. Oxford, 1979.
- 18.Human Vitamin and Mineral Requirements. World Health Organization, Food and Agriculture Organization of the United Nations. Rome, 2002.
